Pharmacology
Griseofulvin is a fungistatic antibiotic, mainly effective on a specific group of fungi, dermatophytes (trichopyton, microsporum, and epidermophyton). It inhibits fungal cell mitosis in causing disruption of the mitotic spindle structure, thereby arresting the metaphase of cell division. Following oral administration, griseofulvin reaches the skin, hair and nails and be deposited in the keratin precursor cells, it has a greater affinity for diseased tissue. Griseofulvin are gradually exfoliated and replaced by non infected tissue. The drug is tightly bound to the new keratin, which becomes highly resistant to fungal invasions. Griseofulvin plasma protein binding 80%, Maximal plasma concentration 0.5-2µg/ml and excreted 50% in feces.
Indications :
Griosefulvin treatment of ringworm infections of the skin, hair and nails, like tinea corporis, tinea pedis, tinea cruris, tinea barbae, tinea capitis, tinea unguinum (onychomycosis) when caused by one or more dermatophytes fungi.
Duration of Terapi
- Tinea capitis : 4-6 weeks
- Tinea Corporis : 2-4 weeks
- Tinea Pedis : 4-8 weeks
- Tinea unguinum : >4 months for fingernails, >6 months for toenails
Side Effects:
Stop taking griseofulvin if you experience an allergic reaction, side effects may be more likely to occur (This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects)
- White patches in your mouth (thrush/yeast infection);
- Nausea, vomiting, or diarrhea;
- Headache, dizziness, or tiredness;
- Insomnia;
- Confusion;
- Numbness or tingling in your hands or feet; or
- Menstrual irregularities.
