Cinnarizine is a selective calcium-channel blocker that has no effect on contractility and conduction of the heart. Cinnarizine can inhibits smooth muscle contraction by blocking the calcium channels. Cinnarizine increases erythrocyte deformability and decreases blood viscosity in vitro and inhibits stimulation of the vestibular system.
Indications:
Control of vestibular symptoms of both peripheral and central origin and of labyrinth disorders including vertigo, dizziness, nystagmus, tinnitus, nausea and vomitting and prophylaxis of motion sickness. Cinnarizine also used for adjunct therapy for symptoms of peripheral arterial disease, prevention and treatment of kinesis.
Dosage:
- Peripheral circulatory disturbances: 2-3 Cinnarizine tablets 25 mg 3 times daily
- Balance/disequilibrium disorders: 1 Cinnarizine tablet 25 mg 3 times daily
- Motion Sickness: 1 Cinnarizine tablet 25 mg 2 hours before travelling, for children half dose
Cinnarizine Side Effects:
Drowsiness and gastrointestinal disturbances. Infrequently reported: headache, dry mouth and weight gain.
Interactions:
Cinnarizine may potentiate the effects of the antidepressants and alcohol. Antiacide medicines and H2-blockers accelerate the resorption of the preparation, reducing acidity of the stomach fluid. Nootrope agents and vasodilators increase Cinnarizin effects.
